BRIEF COMMUNICATIONS PREVENTION OF CHRONIC REJECTION IN MOUSE AORTIC ALLOGRAFTS BY COMBINED TREATl\IENT WITH CTLA4-IG AND ANTI-CD40 LIGAND MONOCLONAL ANTIBODy1,2
نویسنده
چکیده
Thomas E. Stanl Transplantation Institute, Section of Cellular Transplantation. and Departments of Surgery and Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261; Laboratory of Immunogenetics and Transplantation. Brigham and Women's Hospital, Harvard Medical School. Boston, Massachusetts 02115; and Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
منابع مشابه
CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates.
Selective inhibition of T cell costimulation using the B7-specific fusion protein CTLA4-Ig has been shown to induce long-term allograft survival in rodents. Antibodies preventing the interaction between CD40 and its T cell-based ligand CD154 (CD40L) have been shown in rodents to act synergistically with CTLA4-Ig. It has thus been hypothesized that these agents might be capable of inducing long-...
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BLOCKADE of CD28/B7 and/or CD40/CD40L pathways has been employed with reasonable success to prevent organ allograft rejection.1.:! Additionally, contemporaneous but not discrete use of rhCfLA4-Ig and antiCD40L monoclonal antibody (MAb) has also been shown to prevent chronic rejection.1.3 In the realm of cellular transplantation (Tx), it has been reported that the use of either rhCfLA4-Ig or ant...
متن کاملCytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28
Cytotoxic T lymphocyte antigen 4 (CTLA4) appears to negatively regulate T cell activation. One mechanism by which CTLA4 might antagonize T cell function is through inhibition of CD28 signaling by competing for their shared ligands B7-1 and B7-2. In addition, CTLA4 ligation could initiate a signaling cascade that inhibits T cell activation. To address whether CTLA4 could inhibit immune responses...
متن کاملCytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function
Cytotoxic T lymphocyte antigen 4 (CTLA4) appears to negatively regulate T cell activation. One mechanism by which CTLA4 might antagonize T cell function is through inhibition of CD28 signaling by competing for their shared ligands B7-1 and B7-2. In addition, CTLA4 ligation could initiate a signaling cascade that inhibits T cell activation. To address whether CTLA4 could inhibit immune responses...
متن کاملAnti-CD28 antibodies modify regulatory mechanisms and reinforce tolerance in CD40Ig-treated heart allograft recipients.
Blockade of CD40-CD40 ligand (CD40L) costimulation has been shown to synergize with that of CTLA4/CD28-B7 to promote transplant tolerance. To date, however, CD28-B7 interactions have been prevented using B7-blocking reagents like CTLA4-Ig that inhibit CD28-B7 together with CTLA4-B7 interactions. In this study, we have tested anti-CD28 Abs to prevent selectively CD28-B7 interactions while preser...
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